Within the LSD-certain crystal composition, the side chain on the lid residue L209EL2 sorts substantial hydrophobic contacts with both of those LSD and bordering residues in TMs III, IV, and V (Determine 4C). When the lid moved apart to expose the binding pocket in simulation, numerous of these contacts broke. https://ilovebookmark.com/story19455168/lsd-crystal-for-dummies