Plants have been Traditionally a supply of analgesic alkaloids, While their pharmacological characterization is often limited. Among such organic analgesic molecules, conolidine, located in the bark in the tropical flowering shrub Tabernaemontana divaricata We demonstrated that, in distinction to classical opioid receptors, ACKR3 does not induce classical G protein https://www.proleviate.com/post/is-conolidine-a-real-pain-reliever