Utilization of robust CYP1A2 inhibitors must be discontinued in advance of initiating pirfenidone and averted in the course of treatment method; if solid CYP1A2 inhibitors are the one drug of selection, dosage reductions are advisable phenobarbital will lessen the extent or impact of pirfenidone by impacting hepatic enzyme CYP1A2 metabolism. https://llahz110cpz1.wikifrontier.com/user