Chemotherapy was potentiated by E7449 and single agent experienced major antitumor action in BRCA-deficient xenografts. On top of that, E7449 inhibited Wnt/β-catenin signaling in colon most cancers cell lines, very likely by means of TNKS inhibition. Consistent with this probability, E7449 stabilized axin and TNKS proteins causing β-catenin de-stabilization and https://michaela196ibr5.blogozz.com/profile